ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-hydroxytryptamine receptor 1E

Intramolecular
Cysteine 95 and cysteine 173
Cysteine 105 and cysteine 108
Cysteine 105 and cysteine 106
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1E between cysteines 95 and 173.

Details

Redox score ?
86
PDB code
7e33
Structure name
serotonin 1e (5-ht1e) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28566
Residue number A
95
Residue number B
173
Peptide name
5-hydroxytryptamine receptor 1E

Ligandability

Cysteine 95 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1E between cysteines 105 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7e33
Structure name
serotonin 1e (5-ht1e) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
78
Peptide accession
P28566
Residue number A
105
Residue number B
108
Peptide name
5-hydroxytryptamine receptor 1E

Ligandability

Cysteine 105 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1E between cysteines 105 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7e33
Structure name
serotonin 1e (5-ht1e) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
88
Peptide accession
P28566
Residue number A
105
Residue number B
106
Peptide name
5-hydroxytryptamine receptor 1E

Ligandability

Cysteine 105 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of 5-hydroxytryptamine receptor 1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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