ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA excision repair protein ERCC-5

Intramolecular
Cysteine 63 and cysteine 962
Cysteine 12 and cysteine 871
A redox-regulated disulphide may form within DNA excision repair protein ERCC-5 between cysteines 63 and 962. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6tuw
Structure name
human xpg-dna, complex 1
Structure deposition date
2020-01-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
68
Peptide accession
P28715
Residue number A
63
Residue number B
962
Peptide name
DNA excision repair protein ERCC-5

Ligandability

Cysteine 63 of DNA excision repair protein ERCC-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 962 of DNA excision repair protein ERCC-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA excision repair protein ERCC-5 between cysteines 12 and 871. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6tux
Structure name
human xpg-dna, complex 2
Structure deposition date
2020-01-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
42
Peptide accession
P28715
Residue number A
12
Residue number B
871
Peptide name
DNA excision repair protein ERCC-5

Ligandability

Cysteine 12 of DNA excision repair protein ERCC-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 871 of DNA excision repair protein ERCC-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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