ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Progranulin

Intramolecular
Cysteine 284 and cysteine 296
Cysteine 366 and cysteine 378
Cysteine 133 and cysteine 149
Cysteine 372 and cysteine 388
Cysteine 126 and cysteine 139
Cysteine 404 and cysteine 416
Cysteine 397 and cysteine 410
Cysteine 290 and cysteine 306
Cysteine 322 and cysteine 335
Cysteine 315 and cysteine 328
More...
Cysteine 307 and cysteine 321
Cysteine 297 and cysteine 314
Cysteine 366 and cysteine 372
Cysteine 133 and cysteine 139
Cysteine 290 and cysteine 296
Cysteine 126 and cysteine 133
Cysteine 284 and cysteine 290
Cysteine 379 and cysteine 389
Cysteine 389 and cysteine 396
Cysteine 139 and cysteine 149
Cysteine 396 and cysteine 397
Cysteine 403 and cysteine 404
Cysteine 140 and cysteine 150
Cysteine 372 and cysteine 378
Cysteine 404 and cysteine 410
Cysteine 297 and cysteine 321
Cysteine 307 and cysteine 314
Cysteine 296 and cysteine 306
Cysteine 126 and cysteine 149
Cysteine 396 and cysteine 410
Cysteine 314 and cysteine 322
Cysteine 284 and cysteine 306
Cysteine 410 and cysteine 416
Cysteine 314 and cysteine 321
Cysteine 297 and cysteine 322
Cysteine 297 and cysteine 307
Cysteine 372 and cysteine 379
Cysteine 397 and cysteine 403
Cysteine 378 and cysteine 388
Cysteine 306 and cysteine 307
A redox-regulated disulphide may form within Progranulin between cysteines 284 and 296 (1 and 13 respectively in this structure).

Details

Redox score ?
91
PDB code
6nug
Structure name
hgrna4-28_3s
Structure deposition date
2019-02-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
284
Residue number B
296
Peptide name
Progranulin

Ligandability

Cysteine 284 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 366 and 378 (3 and 15 respectively in this structure).

Details

Redox score ?
88
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
366
Residue number B
378
Peptide name
Progranulin

Ligandability

Cysteine 366 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 378 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 133 and 149 (11 and 27 respectively in this structure).

Details

Redox score ?
88
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
133
Residue number B
149
Peptide name
Progranulin

Ligandability

Cysteine 133 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 372 and 388 (9 and 25 respectively in this structure).

Details

Redox score ?
88
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
372
Residue number B
388
Peptide name
Progranulin

Ligandability

Cysteine 372 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 126 and 139 (4 and 17 respectively in this structure).

Details

Redox score ?
87
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
126
Residue number B
139
Peptide name
Progranulin

Ligandability

Cysteine 126 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 404 and 416 (41 and 53 respectively in this structure).

Details

Redox score ?
87
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
404
Residue number B
416
Peptide name
Progranulin

Ligandability

Cysteine 404 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 397 and 410 (34 and 47 respectively in this structure).

Details

Redox score ?
85
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
397
Residue number B
410
Peptide name
Progranulin

Ligandability

Cysteine 397 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 290 and 306 (12 and 28 respectively in this structure).

Details

Redox score ?
84
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
290
Residue number B
306
Peptide name
Progranulin

Ligandability

Cysteine 290 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 322 and 335 (44 and 57 respectively in this structure).

Details

Redox score ?
84
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
322
Residue number B
335
Peptide name
Progranulin

Ligandability

Cysteine 322 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 315 and 328 (37 and 50 respectively in this structure).

Details

Redox score ?
83
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
315
Residue number B
328
Peptide name
Progranulin

Ligandability

Cysteine 315 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 307 and 321 (29 and 43 respectively in this structure).

Details

Redox score ?
81
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
307
Residue number B
321
Peptide name
Progranulin

Ligandability

Cysteine 307 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 297 and 314 (19 and 36 respectively in this structure).

Details

Redox score ?
81
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
297
Residue number B
314
Peptide name
Progranulin

Ligandability

Cysteine 297 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 366 and 372 (3 and 9 respectively in this structure).

Details

Redox score ?
80
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
366
Residue number B
372
Peptide name
Progranulin

Ligandability

Cysteine 366 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 133 and 139 (11 and 17 respectively in this structure).

Details

Redox score ?
79
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
133
Residue number B
139
Peptide name
Progranulin

Ligandability

Cysteine 133 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 290 and 296 (10 and 16 respectively in this structure).

Details

Redox score ?
79
PDB code
1g26
Structure name
the solution structure of a well-folded peptide based on the 31- residue amino-terminal subdomain of human granulin a
Structure deposition date
2000-10-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
290
Residue number B
296
Peptide name
Progranulin

Ligandability

Cysteine 290 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 126 and 133 (4 and 11 respectively in this structure).

Details

Redox score ?
75
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
126
Residue number B
133
Peptide name
Progranulin

Ligandability

Cysteine 126 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 284 and 290 (1 and 7 respectively in this structure).

Details

Redox score ?
71
PDB code
6nug
Structure name
hgrna4-28_3s
Structure deposition date
2019-02-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
284
Residue number B
290
Peptide name
Progranulin

Ligandability

Cysteine 284 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 379 and 389 (16 and 26 respectively in this structure).

Details

Redox score ?
70
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
P28799
Residue number A
379
Residue number B
389
Peptide name
Progranulin

Ligandability

Cysteine 379 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 389 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 389 and 396 (26 and 33 respectively in this structure).

Details

Redox score ?
69
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
P28799
Residue number A
389
Residue number B
396
Peptide name
Progranulin

Ligandability

Cysteine 389 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 139 and 149 (17 and 27 respectively in this structure).

Details

Redox score ?
68
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
139
Residue number B
149
Peptide name
Progranulin

Ligandability

Cysteine 139 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 396 and 397 (33 and 34 respectively in this structure).

Details

Redox score ?
68
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
nan
Peptide accession
P28799
Residue number A
396
Residue number B
397
Peptide name
Progranulin

Ligandability

Cysteine 396 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 403 and 404 (40 and 41 respectively in this structure).

Details

Redox score ?
67
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
nan
Peptide accession
P28799
Residue number A
403
Residue number B
404
Peptide name
Progranulin

Ligandability

Cysteine 403 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 404 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 140 and 150 (18 and 28 respectively in this structure).

Details

Redox score ?
66
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
P28799
Residue number A
140
Residue number B
150
Peptide name
Progranulin

Ligandability

Cysteine 140 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 372 and 378 (9 and 15 respectively in this structure).

Details

Redox score ?
66
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
372
Residue number B
378
Peptide name
Progranulin

Ligandability

Cysteine 372 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 378 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 404 and 410 (41 and 47 respectively in this structure).

Details

Redox score ?
66
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
404
Residue number B
410
Peptide name
Progranulin

Ligandability

Cysteine 404 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 297 and 321 (19 and 43 respectively in this structure).

Details

Redox score ?
65
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
297
Residue number B
321
Peptide name
Progranulin

Ligandability

Cysteine 297 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 307 and 314 (29 and 36 respectively in this structure).

Details

Redox score ?
64
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
307
Residue number B
314
Peptide name
Progranulin

Ligandability

Cysteine 307 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 296 and 306 (13 and 23 respectively in this structure).

Details

Redox score ?
64
PDB code
6nug
Structure name
hgrna4-28_3s
Structure deposition date
2019-02-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
296
Residue number B
306
Peptide name
Progranulin

Ligandability

Cysteine 296 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 126 and 149 (4 and 27 respectively in this structure).

Details

Redox score ?
64
PDB code
2jyv
Structure name
human granulin f
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
126
Residue number B
149
Peptide name
Progranulin

Ligandability

Cysteine 126 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 396 and 410 (33 and 47 respectively in this structure).

Details

Redox score ?
63
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
nan
Peptide accession
P28799
Residue number A
396
Residue number B
410
Peptide name
Progranulin

Ligandability

Cysteine 396 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 314 and 322 (36 and 44 respectively in this structure).

Details

Redox score ?
63
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
314
Residue number B
322
Peptide name
Progranulin

Ligandability

Cysteine 314 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 284 and 306 (4 and 26 respectively in this structure).

Details

Redox score ?
63
PDB code
1g26
Structure name
the solution structure of a well-folded peptide based on the 31- residue amino-terminal subdomain of human granulin a
Structure deposition date
2000-10-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
284
Residue number B
306
Peptide name
Progranulin

Ligandability

Cysteine 284 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 410 and 416 (47 and 53 respectively in this structure).

Details

Redox score ?
63
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
410
Residue number B
416
Peptide name
Progranulin

Ligandability

Cysteine 410 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 314 and 321 (36 and 43 respectively in this structure).

Details

Redox score ?
63
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
314
Residue number B
321
Peptide name
Progranulin

Ligandability

Cysteine 314 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 297 and 322 (19 and 44 respectively in this structure).

Details

Redox score ?
63
PDB code
2jye
Structure name
human granulin a
Structure deposition date
2007-12-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
297
Residue number B
322
Peptide name
Progranulin

Ligandability

Cysteine 297 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 297 and 307 (17 and 27 respectively in this structure).

Details

Redox score ?
62
PDB code
1g26
Structure name
the solution structure of a well-folded peptide based on the 31- residue amino-terminal subdomain of human granulin a
Structure deposition date
2000-10-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
P28799
Residue number A
297
Residue number B
307
Peptide name
Progranulin

Ligandability

Cysteine 297 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 372 and 379 (9 and 16 respectively in this structure).

Details

Redox score ?
61
PDB code
2jyu
Structure name
human granulin c, isomer 2
Structure deposition date
2007-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
nan
Peptide accession
P28799
Residue number A
372
Residue number B
379
Peptide name
Progranulin

Ligandability

Cysteine 372 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 379 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 397 and 403 (34 and 40 respectively in this structure).

Details

Redox score ?
60
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
nan
Peptide accession
P28799
Residue number A
397
Residue number B
403
Peptide name
Progranulin

Ligandability

Cysteine 397 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 403 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 378 and 388 (15 and 25 respectively in this structure).

Details

Redox score ?
60
PDB code
2jyt
Structure name
human granulin c, isomer 1
Structure deposition date
2007-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
378
Residue number B
388
Peptide name
Progranulin

Ligandability

Cysteine 378 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Progranulin between cysteines 306 and 307 (23 and 24 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6nug
Structure name
hgrna4-28_3s
Structure deposition date
2019-02-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28799
Residue number A
306
Residue number B
307
Peptide name
Progranulin

Ligandability

Cysteine 306 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Progranulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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