Receptor-type tyrosine-protein phosphatase mu
Intramolecular
Cysteine 206 and cysteine 260
Cysteine 376 and cysteine 410
Cysteine 96 and cysteine 182
Cysteine 27 and cysteine 36
Cysteine 1008 and cysteine 1009
Cysteine 1008 and cysteine 1095
Cysteine 1095 and cysteine 1104
2c9a A 206 A 260
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 206 and 260.
Details
Redox score ?
87
PDB code
2c9a
Structure name
crystal structure of the mam-ig module of receptor protein tyrosine phosphatase mu
Structure deposition date
2005-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28827
Residue number A
206
Residue number B
260
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 206 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 260 of Receptor-type tyrosine-protein phosphatase mu
2v5y A 356 A 390
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 376 and 410 (356 and 390 respectively in this structure).
Details
Redox score ?
86
PDB code
2v5y
Structure name
crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
Structure deposition date
2007-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28827
Residue number A
376
Residue number B
410
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 376 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 410 of Receptor-type tyrosine-protein phosphatase mu
2v5y A 76 A 162
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 96 and 182 (76 and 162 respectively in this structure).
Details
Redox score ?
85
PDB code
2v5y
Structure name
crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
Structure deposition date
2007-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28827
Residue number A
96
Residue number B
182
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 96 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 182 of Receptor-type tyrosine-protein phosphatase mu
2c9a A 27 A 36
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 27 and 36.
Details
Redox score ?
84
PDB code
2c9a
Structure name
crystal structure of the mam-ig module of receptor protein tyrosine phosphatase mu
Structure deposition date
2005-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28827
Residue number A
27
Residue number B
36
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 27 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 36 of Receptor-type tyrosine-protein phosphatase mu
1rpm B 1008 B 1009
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 1008 and 1009. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
1rpm
Structure name
human receptor protein tyrosine phosphatase mu, domain 1
Structure deposition date
1997-09-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
74
Peptide accession
P28827
Residue number A
1008
Residue number B
1009
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 1008 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 1009 of Receptor-type tyrosine-protein phosphatase mu
1rpm B 1008 B 1095
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 1008 and 1095. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1rpm
Structure name
human receptor protein tyrosine phosphatase mu, domain 1
Structure deposition date
1997-09-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
95
Peptide accession
P28827
Residue number A
1008
Residue number B
1095
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 1008 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 1095 of Receptor-type tyrosine-protein phosphatase mu
1rpm A 1095 A 1104
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase mu between cysteines 1095 and 1104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1rpm
Structure name
human receptor protein tyrosine phosphatase mu, domain 1
Structure deposition date
1997-09-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
8
% buried
100
Peptide accession
P28827
Residue number A
1095
Residue number B
1104
Peptide name
Receptor-type tyrosine-protein phosphatase mu
Ligandability
Cysteine 1095 of Receptor-type tyrosine-protein phosphatase mu
Cysteine 1104 of Receptor-type tyrosine-protein phosphatase mu
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