ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytosol aminopeptidase

Intramolecular
Cysteine 129 and cysteine 145
A redox-regulated disulphide may form within Cytosol aminopeptidase between cysteines 129 and 145 (97 and 113 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
1lcp
Structure name
bovine lens leucine aminopeptidase complexed with l-leucine phosphonic acid
Structure deposition date
1995-05-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
P00727
Residue number A
129
Residue number B
145
Peptide name
Cytosol aminopeptidase

Ligandability

Cysteine 129 of Cytosol aminopeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Cytosol aminopeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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