11-beta-hydroxysteroid dehydrogenase 1

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of 11-beta-hydroxysteroid dehydrogenase 1 at cysteines 272 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3tfq

Structure name

crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro- 1h-pyrano[3,4-c]pyridine-5-carbonitrile

Structure deposition date

2011-08-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

11-beta-hydroxysteroid dehydrogenase 1

Peptide B name

11-beta-hydroxysteroid dehydrogenase 1

Peptide A accession

P28845

Peptide B accession

P28845

Peptide A residue number

272

Peptide B residue number

272

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 11-beta-hydroxysteroid dehydrogenase 1 between cysteines 213 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?