ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

T-cell surface glycoprotein CD1b

Intramolecular
Cysteine 149 and cysteine 163
Cysteine 120 and cysteine 184
Cysteine 224 and cysteine 279
Cysteine 224 and cysteine 224
Cysteine 140 and cysteine 163
A redox-regulated disulphide may form within T-cell surface glycoprotein CD1b between cysteines 149 and 163 (131 and 145 respectively in this structure).

Details

Redox score ?
86
PDB code
1gzq
Structure name
cd1b in complex with phophatidylinositol
Structure deposition date
2002-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29016
Residue number A
149
Residue number B
163
Peptide name
T-cell surface glycoprotein CD1b

Ligandability

Cysteine 149 of T-cell surface glycoprotein CD1b

Cysteine 163 of T-cell surface glycoprotein CD1b

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1b between cysteines 120 and 184 (102 and 166 respectively in this structure).

Details

Redox score ?
82
PDB code
1gzp
Structure name
cd1b in complex with gm2 ganglioside
Structure deposition date
2002-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29016
Residue number A
120
Residue number B
184
Peptide name
T-cell surface glycoprotein CD1b

Ligandability

Cysteine 120 of T-cell surface glycoprotein CD1b

Cysteine 184 of T-cell surface glycoprotein CD1b

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1b between cysteines 224 and 279 (206 and 261 respectively in this structure).

Details

Redox score ?
81
PDB code
6cug
Structure name
crystal structure of bc8b tcr-cd1b-pc complex
Structure deposition date
2018-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29016
Residue number A
224
Residue number B
279
Peptide name
T-cell surface glycoprotein CD1b

Ligandability

Cysteine 224 of T-cell surface glycoprotein CD1b

Cysteine 279 of T-cell surface glycoprotein CD1b

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1b between cysteines 224 and 224 (1025 and 1080 respectively in this structure).

Details

Redox score ?
79
PDB code
3ov6
Structure name
cd1c in complex with mpm (mannosyl-beta1-phosphomycoketide)
Structure deposition date
2010-09-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29016
Residue number A
224
Residue number B
224
Peptide name
T-cell surface glycoprotein CD1b

Ligandability

Cysteine 224 of T-cell surface glycoprotein CD1b

Cysteine 224 of T-cell surface glycoprotein CD1b

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1b between cysteines 140 and 163 (140 and 148 respectively in this structure).

Details

Redox score ?
nan
PDB code
5c9j
Structure name
human cd1c with ligands in a' and f' channel
Structure deposition date
2015-06-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
20
Peptide accession
P29016
Residue number A
140
Residue number B
163
Peptide name
T-cell surface glycoprotein CD1b

Ligandability

Cysteine 140 of T-cell surface glycoprotein CD1b

Cysteine 163 of T-cell surface glycoprotein CD1b

Cysteine 140 in protein A could not be asigned to a Uniprot residue.
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