ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface glycoprotein CD1c

Intramolecular
Cysteine 120 and cysteine 185
Cysteine 225 and cysteine 280
A redox-regulated disulphide may form within T-cell surface glycoprotein CD1c between cysteines 120 and 185 (102 and 167 respectively in this structure).

Details

Redox score ?
83
PDB code
6c15
Structure name
cd1c in complex with phosphatidylcholine
Structure deposition date
2018-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29017
Residue number A
120
Residue number B
185
Peptide name
T-cell surface glycoprotein CD1c

Ligandability

Cysteine 120 of T-cell surface glycoprotein CD1c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of T-cell surface glycoprotein CD1c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1c between cysteines 225 and 280 (207 and 262 respectively in this structure).

Details

Redox score ?
80
PDB code
6c09
Structure name
ternary crystal structure of the 3c8 tcr-cd1c-monoacylglycerol complex
Structure deposition date
2017-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29017
Residue number A
225
Residue number B
280
Peptide name
T-cell surface glycoprotein CD1c

Ligandability

Cysteine 225 of T-cell surface glycoprotein CD1c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of T-cell surface glycoprotein CD1c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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