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Gap junction beta-2 protein

Intramolecular
Cysteine 64 and cysteine 169
Cysteine 53 and cysteine 180
Cysteine 60 and cysteine 174
Cysteine 64 and cysteine 174
Cysteine 169 and cysteine 174
Cysteine 64 and cysteine 180
Cysteine 60 and cysteine 64
Cysteine 53 and cysteine 64
Cysteine 60 and cysteine 169
Cysteine 174 and cysteine 180
More...
Cysteine 53 and cysteine 60
Cysteine 53 and cysteine 174
Cysteine 169 and cysteine 180
Cysteine 60 and cysteine 180
Cysteine 53 and cysteine 169
A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 64 and 169.

Details

Redox score ?
88
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
64
Residue number B
169
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 64 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 53 and 180.

Details

Redox score ?
87
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
53
Residue number B
180
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 53 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 60 and 174.

Details

Redox score ?
85
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
60
Residue number B
174
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 60 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 64 and 174.

Details

Redox score ?
80
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
64
Residue number B
174
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 64 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 169 and 174.

Details

Redox score ?
76
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
169
Residue number B
174
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 169 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 64 and 180.

Details

Redox score ?
72
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
64
Residue number B
180
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 64 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 60 and 64.

Details

Redox score ?
70
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
60
Residue number B
64
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 60 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 53 and 64.

Details

Redox score ?
69
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
53
Residue number B
64
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 53 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 60 and 169.

Details

Redox score ?
69
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
60
Residue number B
169
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 60 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 174 and 180.

Details

Redox score ?
65
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
174
Residue number B
180
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 174 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 53 and 60.

Details

Redox score ?
64
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
53
Residue number B
60
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 53 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 53 and 174.

Details

Redox score ?
62
PDB code
5era
Structure name
human connexin-26 (calcium-free)
Structure deposition date
2015-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
53
Residue number B
174
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 53 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 169 and 180.

Details

Redox score ?
62
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
169
Residue number B
180
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 169 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 60 and 180.

Details

Redox score ?
62
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
60
Residue number B
180
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 60 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction beta-2 protein between cysteines 53 and 169. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5er7
Structure name
connexin-26 bound to calcium
Structure deposition date
2015-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29033
Residue number A
53
Residue number B
169
Peptide name
Gap junction beta-2 protein

Ligandability

Cysteine 53 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction beta-2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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