ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Tyrosine-protein phosphatase non-receptor type 4

Intermolecular
Cysteine 590 and cysteine 590
Intramolecular
Cysteine 870 and cysteine 874
Cysteine 734 and cysteine 763
Cysteine 763 and cysteine 852
Cysteine 726 and cysteine 852
Cysteine 726 and cysteine 763
A redox-regulated disulphide may form between two units of Tyrosine-protein phosphatase non-receptor type 4 at cysteines 590 and 590.

Details

Redox score ?
83
PDB code
5eyz
Structure name
crystal structure of the ptpn4 pdz domain complexed with the tailored peptide cyto8-retev
Structure deposition date
2015-11-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tyrosine-protein phosphatase non-receptor type 4
Peptide B name
Tyrosine-protein phosphatase non-receptor type 4
Peptide A accession
P29074
Peptide B accession
P29074
Peptide A residue number
590
Peptide B residue number
590

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 4 between cysteines 870 and 874. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2i75
Structure name
crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
Structure deposition date
2006-08-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
28
Peptide accession
P29074
Residue number A
870
Residue number B
874
Peptide name
Tyrosine-protein phosphatase non-receptor type 4

Ligandability

Cysteine 870 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 874 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 4 between cysteines 734 and 763. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2i75
Structure name
crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
Structure deposition date
2006-08-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
78
Peptide accession
P29074
Residue number A
734
Residue number B
763
Peptide name
Tyrosine-protein phosphatase non-receptor type 4

Ligandability

Cysteine 734 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 763 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 4 between cysteines 763 and 852. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2i75
Structure name
crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
Structure deposition date
2006-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
96
Peptide accession
P29074
Residue number A
763
Residue number B
852
Peptide name
Tyrosine-protein phosphatase non-receptor type 4

Ligandability

Cysteine 763 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 852 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 4 between cysteines 726 and 852. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2i75
Structure name
crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
Structure deposition date
2006-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
9
% buried
100
Peptide accession
P29074
Residue number A
726
Residue number B
852
Peptide name
Tyrosine-protein phosphatase non-receptor type 4

Ligandability

Cysteine 726 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 852 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 4 between cysteines 726 and 763. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2i75
Structure name
crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
Structure deposition date
2006-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
96
Peptide accession
P29074
Residue number A
726
Residue number B
763
Peptide name
Tyrosine-protein phosphatase non-receptor type 4

Ligandability

Cysteine 726 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 763 of Tyrosine-protein phosphatase non-receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: