ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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General transcription factor IIE subunit 1

Intramolecular
Cysteine 129 and cysteine 157
Cysteine 154 and cysteine 157
Cysteine 132 and cysteine 157
Cysteine 132 and cysteine 154
Cysteine 129 and cysteine 132
Cysteine 129 and cysteine 154
Cysteine 42 and cysteine 74
A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 129 and 157.

Details

Redox score ?
91
PDB code
7nvr
Structure name
human mediator with rna polymerase ii pre-initiation complex
Structure deposition date
2021-03-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
2
Peptide accession
P29083
Residue number A
129
Residue number B
157
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 129 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 154 and 157.

Details

Redox score ?
86
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
0
Peptide accession
P29083
Residue number A
154
Residue number B
157
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 154 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 132 and 157.

Details

Redox score ?
85
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
32
Minimum pKa ?
5
% buried
0
Peptide accession
P29083
Residue number A
132
Residue number B
157
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 132 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 132 and 154.

Details

Redox score ?
85
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
0
Peptide accession
P29083
Residue number A
132
Residue number B
154
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 132 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 129 and 132.

Details

Redox score ?
85
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
0
Peptide accession
P29083
Residue number A
129
Residue number B
132
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 129 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 129 and 154.

Details

Redox score ?
80
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
0
Peptide accession
P29083
Residue number A
129
Residue number B
154
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 129 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIE subunit 1 between cysteines 42 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5gpy
Structure name
crystal structure of the human tfiie complex
Structure deposition date
2016-08-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
18
Peptide accession
P29083
Residue number A
42
Residue number B
74
Peptide name
General transcription factor IIE subunit 1

Ligandability

Cysteine 42 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of General transcription factor IIE subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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