ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Inositol monophosphatase 1

Intramolecular
Cysteine 24 and cysteine 125 L
Cysteine 141 and cysteine 201
A redox-regulated disulphide may form within Inositol monophosphatase 1 between cysteines 24 and 125.

Details

Redox score ?
66
PDB code
2hhm
Structure name
structure of inositol monophosphatase, the putative target of lithium therapy
Structure deposition date
1992-10-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29218
Residue number A
24
Residue number B
125
Peptide name
Inositol monophosphatase 1

Ligandability

Cysteine 24 of Inositol monophosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Inositol monophosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol monophosphatase 1 between cysteines 141 and 201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4as5
Structure name
structure of mouse inositol monophosphatase 1
Structure deposition date
2012-04-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
94
Peptide accession
O55023
Residue number A
141
Residue number B
201
Peptide name
Inositol monophosphatase 1

Ligandability

Cysteine 141 of Inositol monophosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Inositol monophosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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