Adenosine receptor A2a
Intramolecular
Cysteine 259 and cysteine 262
Cysteine 74 and cysteine 146
Cysteine 71 and cysteine 159
Cysteine 77 and cysteine 166
Cysteine 74 and cysteine 77
Cysteine 77 and cysteine 146
Cysteine 74 and cysteine 166
Cysteine 71 and cysteine 77
Cysteine 146 and cysteine 166
Cysteine 71 and cysteine 166
More...Cysteine 77 and cysteine 159
Cysteine 159 and cysteine 166
Cysteine 254 and cysteine 259
Cysteine 74 and cysteine 82
Cysteine 82 and cysteine 166
Cysteine 77 and cysteine 82
Cysteine 71 and cysteine 74
Cysteine 82 and cysteine 146
5mzp A 259 A 262
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 259 and 262.
Details
Redox score ?
90
PDB code
5mzp
Structure name
crystal structure of stabilized a2a adenosine receptor a2ar-star2-bril in complex with caffeine at 2
Structure deposition date
2017-02-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
29
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
259
Residue number B
262
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 259 of Adenosine receptor A2a
Cysteine 262 of Adenosine receptor A2a
5olz A 74 A 146
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 74 and 146.
Details
Redox score ?
86
PDB code
5olz
Structure name
structure of the a2a-star2-bril562-compound 4e complex at 1
Structure deposition date
2017-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
74
Residue number B
146
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 74 of Adenosine receptor A2a
Cysteine 146 of Adenosine receptor A2a
7t32 A 71 A 159
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 71 and 159.
Details
Redox score ?
84
PDB code
7t32
Structure name
cryoem structure of the adenosine 2a receptor-bril/anti bril fab complex with zm241385
Structure deposition date
2021-12-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
0
Peptide accession
P29274
Residue number A
71
Residue number B
159
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 71 of Adenosine receptor A2a
Cysteine 159 of Adenosine receptor A2a
5olz A 77 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 77 and 166.
Details
Redox score ?
81
PDB code
5olz
Structure name
structure of the a2a-star2-bril562-compound 4e complex at 1
Structure deposition date
2017-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
77
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 77 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
7px4 A 74 A 77
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 74 and 77.
Details
Redox score ?
60
PDB code
7px4
Structure name
crystal structure of the adenosine a2a receptor (a2a-psb1-bril) in complex with preladenant conjugate psb-2113
Structure deposition date
2021-10-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
74
Residue number B
77
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 74 of Adenosine receptor A2a
Cysteine 77 of Adenosine receptor A2a
6mh8 A 77 A 146
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 77 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6mh8
Structure name
high-viscosity injector-based pink beam serial crystallography of micro-crystals at a synchrotron radiation source
Structure deposition date
2018-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
77
Residue number B
146
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 77 of Adenosine receptor A2a
Cysteine 146 of Adenosine receptor A2a
3qak A 74 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 74 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3qak
Structure name
agonist bound structure of the human adenosine a2a receptor
Structure deposition date
2011-01-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
74
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 74 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
3rfm A 71 A 77
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 71 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3rfm
Structure name
thermostabilised adenosine a2a receptor in complex with caffeine
Structure deposition date
2011-04-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
71
Residue number B
77
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 71 of Adenosine receptor A2a
Cysteine 77 of Adenosine receptor A2a
6lpk A 146 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 146 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6lpk
Structure name
a2ar crystallized in erococ17+4, lcp-sfx at 293 k
Structure deposition date
2020-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
146
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 146 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
3uzc A 71 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 71 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3uzc
Structure name
thermostabilised adenosine a2a receptor in complex with 4-(3-amino-5- phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Structure deposition date
2011-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
71
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 71 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
6wqa A 77 A 159
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 77 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6wqa
Structure name
2
Structure deposition date
2020-04-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
77
Residue number B
159
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 77 of Adenosine receptor A2a
Cysteine 159 of Adenosine receptor A2a
7px4 A 159 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 159 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7px4
Structure name
crystal structure of the adenosine a2a receptor (a2a-psb1-bril) in complex with preladenant conjugate psb-2113
Structure deposition date
2021-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29274
Residue number A
159
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 159 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
3vga A 254 A 259
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 254 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
3vga
Structure name
crystal structure of human adenosine a2a receptor with an allosteric inverse-agonist antibody at 3
Structure deposition date
2011-08-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
nan
Peptide accession
P29274
Residue number A
254
Residue number B
259
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 254 of Adenosine receptor A2a
Cysteine 259 of Adenosine receptor A2a
3uza A 74 A 82
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 74 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3uza
Structure name
thermostabilised adenosine a2a receptor in complex with 6-(2,6- dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
Structure deposition date
2011-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
nan
Peptide accession
P29274
Residue number A
74
Residue number B
82
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 74 of Adenosine receptor A2a
Cysteine 82 of Adenosine receptor A2a
3rfm A 82 A 166
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 82 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3rfm
Structure name
thermostabilised adenosine a2a receptor in complex with caffeine
Structure deposition date
2011-04-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
nan
Peptide accession
P29274
Residue number A
82
Residue number B
166
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 82 of Adenosine receptor A2a
Cysteine 166 of Adenosine receptor A2a
6s0q A 77 A 82
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 77 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6s0q
Structure name
structure of the a2a adenosine receptor determined at swissfel using native-sad at 4
Structure deposition date
2019-06-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
nan
Peptide accession
P29274
Residue number A
77
Residue number B
82
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 77 of Adenosine receptor A2a
Cysteine 82 of Adenosine receptor A2a
7t32 A 71 A 74
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 71 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7t32
Structure name
cryoem structure of the adenosine 2a receptor-bril/anti bril fab complex with zm241385
Structure deposition date
2021-12-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
nan
Peptide accession
P29274
Residue number A
71
Residue number B
74
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 71 of Adenosine receptor A2a
Cysteine 74 of Adenosine receptor A2a
5olz A 82 A 146
A redox-regulated disulphide may form within Adenosine receptor A2a between cysteines 82 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5olz
Structure name
structure of the a2a-star2-bril562-compound 4e complex at 1
Structure deposition date
2017-07-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
nan
Peptide accession
P29274
Residue number A
82
Residue number B
146
Peptide name
Adenosine receptor A2a
Ligandability
Cysteine 82 of Adenosine receptor A2a
Cysteine 146 of Adenosine receptor A2a
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