ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein phosphatase non-receptor type 6

Intramolecular
Cysteine 327 and cysteine 361
Cysteine 361 and cysteine 453
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 6 between cysteines 327 and 361.

Details

Redox score ?
65
PDB code
4hjp
Structure name
shp-1 catalytic domain wpd loop open
Structure deposition date
2012-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
100
Peptide accession
P29350
Residue number A
327
Residue number B
361
Peptide name
Tyrosine-protein phosphatase non-receptor type 6

Ligandability

Cysteine 327 of Tyrosine-protein phosphatase non-receptor type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Tyrosine-protein phosphatase non-receptor type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 6 between cysteines 361 and 453. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2b3o
Structure name
crystal structure of human tyrosine phosphatase shp-1
Structure deposition date
2005-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
100
Peptide accession
P29350
Residue number A
361
Residue number B
453
Peptide name
Tyrosine-protein phosphatase non-receptor type 6

Ligandability

Cysteine 361 of Tyrosine-protein phosphatase non-receptor type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Tyrosine-protein phosphatase non-receptor type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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