ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cellular retinoic acid-binding protein 2

Intramolecular
Cysteine 82 and cysteine 96
A redox-regulated disulphide may form within Cellular retinoic acid-binding protein 2 between cysteines 82 and 96 (81 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3f9d
Structure name
crystal structure of the r132k:r111l:t54e mutant of cellular retinoic acid-binding protein ii complexed with c15-aldehyde (a retinal analog) at 2
Structure deposition date
2008-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
70
Peptide accession
P29373
Residue number A
82
Residue number B
96
Peptide name
Cellular retinoic acid-binding protein 2

Ligandability

Cysteine 82 of Cellular retinoic acid-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Cellular retinoic acid-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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