ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AT-rich interactive domain-containing protein 4A

Intermolecular
Cysteine 846 of Retinoblastoma-like protein 1 and cysteine 959
Intramolecular
Cysteine 356 and cysteine 400
Cysteine 25 and cysteine 107
Cysteine 200 and cysteine 356
Cysteine 200 and cysteine 400
A redox-regulated disulphide may form between cysteine 846 of Retinoblastoma-like protein 1 and cysteine 959 of AT-rich interactive domain-containing protein 4A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7smc
Structure name
p107 pocket domain complexed with arid4a peptide
Structure deposition date
2021-10-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
68
Peptide A name
Retinoblastoma-like protein 1
Peptide B name
AT-rich interactive domain-containing protein 4A
Peptide A accession
P28749
Peptide B accession
P29374
Peptide A residue number
846
Peptide B residue number
959

Ligandability

Cysteine 846 of Retinoblastoma-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 959 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AT-rich interactive domain-containing protein 4A between cysteines 356 and 400 (163 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6l87
Structure name
solution structure of the tandem pwwp-arid domains of human rbbp1
Structure deposition date
2019-11-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
70
Peptide accession
P29374
Residue number A
356
Residue number B
400
Peptide name
AT-rich interactive domain-containing protein 4A

Ligandability

Cysteine 356 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AT-rich interactive domain-containing protein 4A between cysteines 25 and 107 (22 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2mam
Structure name
solution structure of the interdigitated double tudor domain of rbbp1
Structure deposition date
2013-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
6
Peptide accession
P29374
Residue number A
25
Residue number B
107
Peptide name
AT-rich interactive domain-containing protein 4A

Ligandability

Cysteine 25 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AT-rich interactive domain-containing protein 4A between cysteines 200 and 356 (30 and 163 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6l87
Structure name
solution structure of the tandem pwwp-arid domains of human rbbp1
Structure deposition date
2019-11-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
72
Peptide accession
P29374
Residue number A
200
Residue number B
356
Peptide name
AT-rich interactive domain-containing protein 4A

Ligandability

Cysteine 200 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AT-rich interactive domain-containing protein 4A between cysteines 200 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7v8n
Structure name
crystal structure of the pwwp-arid domain of arid4a
Structure deposition date
2021-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
97
Peptide accession
P29374
Residue number A
200
Residue number B
400
Peptide name
AT-rich interactive domain-containing protein 4A

Ligandability

Cysteine 200 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of AT-rich interactive domain-containing protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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