ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukocyte tyrosine kinase receptor

Intramolecular
Cysteine 73 and cysteine 86
Cysteine 168 and cysteine 179
Cysteine 300 and cysteine 322
A redox-regulated disulphide may form within Leukocyte tyrosine kinase receptor between cysteines 73 and 86.

Details

Redox score ?
81
PDB code
7nx0
Structure name
ltk:alkal1 complex stabilized by a nanobody
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29376
Residue number A
73
Residue number B
86
Peptide name
Leukocyte tyrosine kinase receptor

Ligandability

Cysteine 73 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte tyrosine kinase receptor between cysteines 168 and 179.

Details

Redox score ?
80
PDB code
7nx0
Structure name
ltk:alkal1 complex stabilized by a nanobody
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29376
Residue number A
168
Residue number B
179
Peptide name
Leukocyte tyrosine kinase receptor

Ligandability

Cysteine 168 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte tyrosine kinase receptor between cysteines 300 and 322.

Details

Redox score ?
75
PDB code
7nx0
Structure name
ltk:alkal1 complex stabilized by a nanobody
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
109
Minimum pKa ?
nan
% buried
nan
Peptide accession
P29376
Residue number A
300
Residue number B
322
Peptide name
Leukocyte tyrosine kinase receptor

Ligandability

Cysteine 300 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Leukocyte tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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