Caspase-1
Intermolecular
Cysteine 136 and cysteine 364 L
Cysteine 397 and cysteine 364
Intramolecular
Cysteine 69 and cysteine 72
Cysteine 136 and cysteine 362 L
Cysteine 362 and cysteine 364
Cysteine 72 and cysteine 77
Cysteine 244 and cysteine 285
1ice A 136 B 364
A redox-regulated disulphide may form between two units of Caspase-1 at cysteines 136 and 364. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1ice
Structure name
structure and mechanism of interleukin-1beta converting enzyme
Structure deposition date
1994-09-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
nan
Peptide A name
Caspase-1
Peptide B name
Caspase-1
Peptide A accession
P29466
Peptide B accession
P29466
Peptide A residue number
136
Peptide B residue number
364
Ligandability
Cysteine 136 of Caspase-1
Cysteine 364 of Caspase-1
3e4c A 397 B 364
A redox-regulated disulphide may form between two units of Caspase-1 at cysteines 397 and 364. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
3e4c
Structure name
procaspase-1 zymogen domain crystal structure
Structure deposition date
2008-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
88
Peptide A name
Caspase-1
Peptide B name
Caspase-1
Peptide A accession
P29466
Peptide B accession
P29466
Peptide A residue number
397
Peptide B residue number
364
Ligandability
Cysteine 397 of Caspase-1
Cysteine 364 of Caspase-1
5fna G 68 G 71
A redox-regulated disulphide may form within Caspase-1 between cysteines 69 and 72 (68 and 71 respectively in this structure).
Details
Redox score ?
74
PDB code
5fna
Structure name
cryo-em reconstruction of caspase-1 card
Structure deposition date
2015-11-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
66
Peptide accession
P29466
Residue number A
69
Residue number B
72
Peptide name
Caspase-1
Ligandability
Cysteine 69 of Caspase-1
Cysteine 72 of Caspase-1
3e4c B 136 B 362
A redox-regulated disulphide may form within Caspase-1 between cysteines 136 and 362.
Details
Redox score ?
62
PDB code
3e4c
Structure name
procaspase-1 zymogen domain crystal structure
Structure deposition date
2008-08-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
36
Peptide accession
P29466
Residue number A
136
Residue number B
362
Peptide name
Caspase-1
Ligandability
Cysteine 136 of Caspase-1
Cysteine 362 of Caspase-1
1ice B 362 B 364
A redox-regulated disulphide may form within Caspase-1 between cysteines 362 and 364. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1ice
Structure name
structure and mechanism of interleukin-1beta converting enzyme
Structure deposition date
1994-09-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
nan
Peptide accession
P29466
Residue number A
362
Residue number B
364
Peptide name
Caspase-1
Ligandability
Cysteine 362 of Caspase-1
Cysteine 364 of Caspase-1
7keu H 72 H 77
A redox-regulated disulphide may form within Caspase-1 between cysteines 72 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7keu
Structure name
cryo-em structure of the caspase-1-card:asc-card octamer
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
46
Peptide accession
P29466
Residue number A
72
Residue number B
77
Peptide name
Caspase-1
Ligandability
Cysteine 72 of Caspase-1
Cysteine 77 of Caspase-1
6bz9 A 244 A 285
A redox-regulated disulphide may form within Caspase-1 between cysteines 244 and 285. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6bz9
Structure name
crystal structure of human caspase-1 in complex with ac-fltd-cmk
Structure deposition date
2017-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
75
Peptide accession
P29466
Residue number A
244
Residue number B
285
Peptide name
Caspase-1
Ligandability
Cysteine 244 of Caspase-1
Cysteine 285 of Caspase-1
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