a tool for identifying drug-targetable redox-active disulphides

RNA-binding motif, single-stranded-interacting protein 1

Intramolecular

Cysteine 194 and cysteine 221

A redox-regulated disulphide may form within RNA-binding motif, single-stranded-interacting protein 1 between cysteines 194 and 221 (137 and 164 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

c-myc dna binding protein complex

Structure deposition date

2020-03-17

Thiol separation (Å)

8

Half-sphere exposure sum ?

67

Minimum pK_a ?

10

% buried

46

Peptide accession

Residue number A

194

Residue number B

221

Peptide name

RNA-binding motif, single-stranded-interacting protein 1

Ligandability

Cysteine 194 of RNA-binding motif, single-stranded-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of RNA-binding motif, single-stranded-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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