a tool for identifying drug-targetable redox-active disulphides

CD40 ligand

Intramolecular

Cysteine 178 and cysteine 218

A redox-regulated disulphide may form within CD40 ligand between cysteines 178 and 218.

Details

Redox score ?

77

PDB code

Structure name

small molecule inhibition of the tnf family cyokine cd40 ligand through a subunit fracture mechanism

Structure deposition date

2010-01-27

Thiol separation (Å)

4

Half-sphere exposure sum ?

37

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

178

Residue number B

218

Peptide name

CD40 ligand

Ligandability

Cysteine 178 of CD40 ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of CD40 ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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