ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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cGMP-gated cation channel alpha-1

Intramolecular
Cysteine 184 and cysteine 312
Cysteine 503 and cysteine 571
A redox-regulated disulphide may form within cGMP-gated cation channel alpha-1 between cysteines 184 and 312 (188 and 316 respectively in this structure).

Details

Redox score ?
64
PDB code
7rhi
Structure name
cryo-em structure of human rod cnga1/b1 channel in cgmp-bound openii state
Structure deposition date
2021-07-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
8
% buried
86
Peptide accession
P29973
Residue number A
184
Residue number B
312
Peptide name
cGMP-gated cation channel alpha-1

Ligandability

Cysteine 184 of cGMP-gated cation channel alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of cGMP-gated cation channel alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within cGMP-gated cation channel alpha-1 between cysteines 503 and 571 (507 and 575 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7rhg
Structure name
cryo-em structure of human rod cnga1/b1 channel in camp-bound state
Structure deposition date
2021-07-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
94
Peptide accession
P29973
Residue number A
503
Residue number B
571
Peptide name
cGMP-gated cation channel alpha-1

Ligandability

Cysteine 503 of cGMP-gated cation channel alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 571 of cGMP-gated cation channel alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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