ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peroxiredoxin-5, mitochondrial

Intermolecular
Cysteine 204 and cysteine 204 L
Cysteine 100 and cysteine 100 L
Intramolecular
Cysteine 100 and cysteine 204 L
Cysteine 100 and cysteine 125 L
A redox-regulated disulphide may form between two units of Peroxiredoxin-5, mitochondrial at cysteines 204 and 204 (151 and 151 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2vl9
Structure name
oxidized form of human peroxiredoxin 5
Structure deposition date
2008-01-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peroxiredoxin-5, mitochondrial
Peptide B name
Peroxiredoxin-5, mitochondrial
Peptide A accession
P30044
Peptide B accession
P30044
Peptide A residue number
204
Peptide B residue number
204

Ligandability

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Peroxiredoxin-5, mitochondrial at cysteines 100 and 100 (47 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2vl9
Structure name
oxidized form of human peroxiredoxin 5
Structure deposition date
2008-01-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peroxiredoxin-5, mitochondrial
Peptide B name
Peroxiredoxin-5, mitochondrial
Peptide A accession
P30044
Peptide B accession
P30044
Peptide A residue number
100
Peptide B residue number
100

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peroxiredoxin-5, mitochondrial between cysteines 100 and 204 (47 and 151 respectively in this structure).

Details

Redox score ?
61
PDB code
1oc3
Structure name
human peroxiredoxin 5
Structure deposition date
2003-02-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
4
Peptide accession
P30044
Residue number A
100
Residue number B
204
Peptide name
Peroxiredoxin-5, mitochondrial

Ligandability

Cysteine 100 of Peroxiredoxin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Peroxiredoxin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peroxiredoxin-5, mitochondrial between cysteines 100 and 125 (47 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1hd2
Structure name
human peroxiredoxin 5
Structure deposition date
2000-11-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
92
Peptide accession
Q9UKX4
Residue number A
100
Residue number B
125
Peptide name
Peroxiredoxin-5, mitochondrial

Ligandability

Cysteine 100 of Peroxiredoxin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Peroxiredoxin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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