ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell differentiation antigen CD6

Intramolecular
Cysteine 330 and cysteine 340
Cysteine 129 and cysteine 137
Cysteine 230 and cysteine 240
Cysteine 170 and cysteine 204
Cysteine 70 and cysteine 144
Cysteine 290 and cysteine 350
Cysteine 54 and cysteine 88
Cysteine 274 and cysteine 308
Cysteine 83 and cysteine 155
Cysteine 186 and cysteine 249
More...
Cysteine 303 and cysteine 360
Cysteine 199 and cysteine 259
Cysteine 308 and cysteine 360
Cysteine 204 and cysteine 259
Cysteine 88 and cysteine 155
Cysteine 274 and cysteine 360
Cysteine 303 and cysteine 308
Cysteine 54 and cysteine 155
Cysteine 83 and cysteine 88
Cysteine 170 and cysteine 259
Cysteine 199 and cysteine 204
Cysteine 274 and cysteine 303
Cysteine 54 and cysteine 83
Cysteine 170 and cysteine 199
A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 330 and 340.

Details

Redox score ?
89
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
330
Residue number B
340
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 330 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 129 and 137.

Details

Redox score ?
89
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
129
Residue number B
137
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 129 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 230 and 240.

Details

Redox score ?
88
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
230
Residue number B
240
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 230 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 170 and 204.

Details

Redox score ?
84
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
170
Residue number B
204
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 170 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 70 and 144.

Details

Redox score ?
84
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
70
Residue number B
144
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 70 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 290 and 350.

Details

Redox score ?
84
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
290
Residue number B
350
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 290 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 350 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 54 and 88.

Details

Redox score ?
84
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
54
Residue number B
88
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 54 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 274 and 308.

Details

Redox score ?
84
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
274
Residue number B
308
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 274 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 83 and 155.

Details

Redox score ?
83
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
83
Residue number B
155
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 83 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 155 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 186 and 249.

Details

Redox score ?
83
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
186
Residue number B
249
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 186 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 303 and 360.

Details

Redox score ?
83
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
303
Residue number B
360
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 303 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 199 and 259.

Details

Redox score ?
82
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
199
Residue number B
259
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 199 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 308 and 360.

Details

Redox score ?
72
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
308
Residue number B
360
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 308 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 204 and 259.

Details

Redox score ?
69
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
204
Residue number B
259
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 204 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 88 and 155.

Details

Redox score ?
69
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
88
Residue number B
155
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 88 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 155 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 274 and 360.

Details

Redox score ?
65
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
274
Residue number B
360
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 274 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 303 and 308.

Details

Redox score ?
64
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
303
Residue number B
308
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 303 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 54 and 155.

Details

Redox score ?
61
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
54
Residue number B
155
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 54 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 155 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 83 and 88.

Details

Redox score ?
61
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
83
Residue number B
88
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 83 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 170 and 259.

Details

Redox score ?
60
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
170
Residue number B
259
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 170 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 199 and 204.

Details

Redox score ?
60
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
199
Residue number B
204
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 199 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 274 and 303. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
274
Residue number B
303
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 274 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 54 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
54
Residue number B
83
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 54 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell differentiation antigen CD6 between cysteines 170 and 199. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5a2e
Structure name
extracellular srcr domains of human cd6
Structure deposition date
2015-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30203
Residue number A
170
Residue number B
199
Peptide name
T-cell differentiation antigen CD6

Ligandability

Cysteine 170 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of T-cell differentiation antigen CD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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