ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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M-phase inducer phosphatase 2

Intramolecular
Cysteine 440 and cysteine 487
Cysteine 440 and cysteine 498
A redox-regulated disulphide may form within M-phase inducer phosphatase 2 between cysteines 440 and 487 (426 and 473 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2uzq
Structure name
protein phosphatase, new crystal form
Structure deposition date
2007-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
P30305
Residue number A
440
Residue number B
487
Peptide name
M-phase inducer phosphatase 2

Ligandability

Cysteine 440 of M-phase inducer phosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of M-phase inducer phosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within M-phase inducer phosphatase 2 between cysteines 440 and 498 (426 and 484 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2uzq
Structure name
protein phosphatase, new crystal form
Structure deposition date
2007-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
P30305
Residue number A
440
Residue number B
498
Peptide name
M-phase inducer phosphatase 2

Ligandability

Cysteine 440 of M-phase inducer phosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 498 of M-phase inducer phosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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