Vasopressin V2 receptor
Intramolecular
Cysteine 82 and cysteine 195
Cysteine 224 and cysteine 283
Cysteine 112 and cysteine 192
Cysteine 341 and cysteine 342
Cysteine 192 and cysteine 195
Cysteine 112 and cysteine 195
Cysteine 142 and cysteine 224
Cysteine 283 and cysteine 319
6u1n R 413 R 416
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 82 and 195 (413 and 416 respectively in this structure).
Details
Redox score ?
85
PDB code
6u1n
Structure name
gpcr-beta arrestin structure in lipid bilayer
Structure deposition date
2019-08-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30518
Residue number A
82
Residue number B
195
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 82 of Vasopressin V2 receptor
Cysteine 195 of Vasopressin V2 receptor
Uncertain whether structure cysteine 413 has been assigned to correct residue.
6u1n R 96 R 176
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 224 and 283 (96 and 176 respectively in this structure).
Details
Redox score ?
85
PDB code
6u1n
Structure name
gpcr-beta arrestin structure in lipid bilayer
Structure deposition date
2019-08-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30518
Residue number A
224
Residue number B
283
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 224 of Vasopressin V2 receptor
Cysteine 283 of Vasopressin V2 receptor
7bb7 A 112 A 192
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 112 and 192.
Details
Redox score ?
84
PDB code
7bb7
Structure name
avp-v2r-galphas-beta1-gamma2-nb35(t state)
Structure deposition date
2020-12-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30518
Residue number A
112
Residue number B
192
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 112 of Vasopressin V2 receptor
Cysteine 192 of Vasopressin V2 receptor
7r0c A 341 A 342
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 341 and 342.
Details
Redox score ?
60
PDB code
7r0c
Structure name
structure of the avp-v2r-arrestin2-scfv30 complex
Structure deposition date
2022-02-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P30518
Residue number A
341
Residue number B
342
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 341 of Vasopressin V2 receptor
Cysteine 342 of Vasopressin V2 receptor
7r0c A 192 A 195
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 192 and 195. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7r0c
Structure name
structure of the avp-v2r-arrestin2-scfv30 complex
Structure deposition date
2022-02-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
nan
Peptide accession
P30518
Residue number A
192
Residue number B
195
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 192 of Vasopressin V2 receptor
Cysteine 195 of Vasopressin V2 receptor
7r0c A 112 A 195
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 112 and 195. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7r0c
Structure name
structure of the avp-v2r-arrestin2-scfv30 complex
Structure deposition date
2022-02-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
nan
Peptide accession
P30518
Residue number A
112
Residue number B
195
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 112 of Vasopressin V2 receptor
Cysteine 195 of Vasopressin V2 receptor
7bb7 A 142 A 224
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 142 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7bb7
Structure name
avp-v2r-galphas-beta1-gamma2-nb35(t state)
Structure deposition date
2020-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
50
Peptide accession
P30518
Residue number A
142
Residue number B
224
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 142 of Vasopressin V2 receptor
Cysteine 224 of Vasopressin V2 receptor
7r0c A 283 A 319
A redox-regulated disulphide may form within Vasopressin V2 receptor between cysteines 283 and 319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7r0c
Structure name
structure of the avp-v2r-arrestin2-scfv30 complex
Structure deposition date
2022-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
57
Peptide accession
P30518
Residue number A
283
Residue number B
319
Peptide name
Vasopressin V2 receptor
Ligandability
Cysteine 283 of Vasopressin V2 receptor
Cysteine 319 of Vasopressin V2 receptor
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