Tyrosine-protein kinase receptor UFO

Intramolecular

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor UFO between cysteines 160 and 205 (153 and 198 respectively in this structure).

Details

Redox score ?

PDB code

2c5d

Structure name

structure of a minimal gas6-axl complex

Structure deposition date

2005-10-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P30530

Residue number A

160

Residue number B

205

Peptide name

Tyrosine-protein kinase receptor UFO

Ligandability

Cysteine 160 of Tyrosine-protein kinase receptor UFO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Tyrosine-protein kinase receptor UFO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor UFO between cysteines 56 and 117 (49 and 110 respectively in this structure).

Details

Redox score ?

PDB code

4ra0

Structure name

an engineered axl 'decoy receptor' effectively silences the gas6-axl signaling axis

Structure deposition date

2014-09-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P30530

Residue number A

Residue number B

117

Peptide name

Tyrosine-protein kinase receptor UFO

Ligandability

Cysteine 56 of Tyrosine-protein kinase receptor UFO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Tyrosine-protein kinase receptor UFO

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor UFO between cysteines 678 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?