Type-1 angiotensin II receptor

Intramolecular

A redox-regulated disulphide may form within Type-1 angiotensin II receptor between cysteines 18 and 274 (18 and 1274 respectively in this structure).

Details

Redox score ?

PDB code

6os2

Structure name

structure of synthetic nanobody-stabilized angiotensin ii type 1 receptor bound to trv026

Structure deposition date

2019-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P30556

Residue number A

Residue number B

274

Peptide name

Type-1 angiotensin II receptor

Ligandability

Cysteine 18 of Type-1 angiotensin II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Type-1 angiotensin II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Type-1 angiotensin II receptor between cysteines 101 and 180.

Details

Redox score ?

PDB code

6os0

Structure name

structure of synthetic nanobody-stabilized angiotensin ii type 1 receptor bound to angiotensin ii

Structure deposition date

2019-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P30556

Residue number A

101

Residue number B

180

Peptide name

Type-1 angiotensin II receptor

Ligandability

Cysteine 101 of Type-1 angiotensin II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Type-1 angiotensin II receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Type-1 angiotensin II receptor between cysteines 121 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?