ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CAP-Gly domain-containing linker protein 1

Intramolecular
Cysteine 1419 and cysteine 1422
Cysteine 1422 and cysteine 1432
Cysteine 1419 and cysteine 1432
A redox-regulated disulphide may form within CAP-Gly domain-containing linker protein 1 between cysteines 1419 and 1422 (1408 and 1411 respectively in this structure).

Details

Redox score ?
74
PDB code
3e2u
Structure name
crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued)
Structure deposition date
2008-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
P30622
Residue number A
1419
Residue number B
1422
Peptide name
CAP-Gly domain-containing linker protein 1

Ligandability

Cysteine 1419 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1422 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CAP-Gly domain-containing linker protein 1 between cysteines 1422 and 1432 (1411 and 1421 respectively in this structure).

Details

Redox score ?
72
PDB code
3e2u
Structure name
crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued)
Structure deposition date
2008-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
70
Peptide accession
P30622
Residue number A
1422
Residue number B
1432
Peptide name
CAP-Gly domain-containing linker protein 1

Ligandability

Cysteine 1422 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1432 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CAP-Gly domain-containing linker protein 1 between cysteines 1419 and 1432 (1408 and 1421 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3e2u
Structure name
crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued)
Structure deposition date
2008-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
19
% buried
nan
Peptide accession
P30622
Residue number A
1419
Residue number B
1432
Peptide name
CAP-Gly domain-containing linker protein 1

Ligandability

Cysteine 1419 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1432 of CAP-Gly domain-containing linker protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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