a tool for identifying drug-targetable redox-active disulphides

GTP cyclohydrolase 1

Intramolecular

Cysteine 132 and cysteine 203

A redox-regulated disulphide may form within GTP cyclohydrolase 1 between cysteines 132 and 203.

Details

Redox score ?

79

PDB code

Structure name

crystal structure of rat gtpchi/gfrp stimulatory complex plus zn

Structure deposition date

2001-11-18

Thiol separation (Å)

3

Half-sphere exposure sum ?

72

Minimum pK_a ?

7

% buried

nan

Peptide accession

Residue number A

132

Residue number B

203

Peptide name

GTP cyclohydrolase 1

Ligandability

Cysteine 132 of GTP cyclohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of GTP cyclohydrolase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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