Aldehyde dehydrogenase X, mitochondrial

Intramolecular

A redox-regulated disulphide may form within Aldehyde dehydrogenase X, mitochondrial between cysteines 318 and 320 (301 and 303 respectively in this structure).

Details

Redox score ?

PDB code

7mjc

Structure name

crystal structure analysis of aldh1b1

Structure deposition date

2021-04-20

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P30837

Residue number A

318

Residue number B

320

Peptide name

Aldehyde dehydrogenase X, mitochondrial

Ligandability

Cysteine 318 of Aldehyde dehydrogenase X, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of Aldehyde dehydrogenase X, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aldehyde dehydrogenase X, mitochondrial between cysteines 318 and 319 (301 and 302 respectively in this structure).

Details

Redox score ?

PDB code

7mjd

Structure name

crystal structure analysis of aldh1b1

Structure deposition date

2021-04-20

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P30837

Residue number A

318

Residue number B

319

Peptide name

Aldehyde dehydrogenase X, mitochondrial

Ligandability

Cysteine 318 of Aldehyde dehydrogenase X, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Aldehyde dehydrogenase X, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aldehyde dehydrogenase X, mitochondrial between cysteines 319 and 320 (302 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?