DNA-directed RNA polymerase II subunit RPB2
Intermolecular
Cysteine 958 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 1430 of DNA-directed RNA polymerase II subunit RPB1 and cysteine 1155 L
Intramolecular
Cysteine 1119 and cysteine 1137
Cysteine 1119 and cysteine 1140
Cysteine 1119 and cysteine 1122
Cysteine 1122 and cysteine 1140
Cysteine 1122 and cysteine 1137
Cysteine 1137 and cysteine 1140
Cysteine 172 and cysteine 177 L
Cysteine 357 and cysteine 572
More...Cysteine 837 and cysteine 892
Cysteine 221 and cysteine 224
Cysteine 510 and cysteine 707
Cysteine 26 and cysteine 696
5iy8 B 958 J 44
A redox-regulated disulphide may form between cysteine 958 of DNA-directed RNA polymerase II subunit RPB2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5iy8
Structure name
human holo-pic in the initial transcribing state
Structure deposition date
2016-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
94
Peptide A name
DNA-directed RNA polymerase II subunit RPB2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
P30876
Peptide B accession
P62875
Peptide A residue number
958
Peptide B residue number
44
Ligandability
Cysteine 958 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5iyb A 1430 B 1155
A redox-regulated disulphide may form between cysteine 1430 of DNA-directed RNA polymerase II subunit RPB1 and cysteine 1155 of DNA-directed RNA polymerase II subunit RPB2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
5iyb
Structure name
human core-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide A name
DNA-directed RNA polymerase II subunit RPB1
Peptide B name
DNA-directed RNA polymerase II subunit RPB2
Peptide A accession
P24928
Peptide B accession
P30876
Peptide A residue number
1430
Peptide B residue number
1155
Ligandability
Cysteine 1430 of DNA-directed RNA polymerase II subunit RPB1
Cysteine 1155 of DNA-directed RNA polymerase II subunit RPB2
5iya B 1119 B 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1119 and 1137.
Details
Redox score ?
90
PDB code
5iya
Structure name
human core-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
1
% buried
59
Peptide accession
P30876
Residue number A
1119
Residue number B
1137
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1137 of DNA-directed RNA polymerase II subunit RPB2
5iy7 B 1119 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1119 and 1140.
Details
Redox score ?
88
PDB code
5iy7
Structure name
human holo-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
1
% buried
38
Peptide accession
P30876
Residue number A
1119
Residue number B
1140
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1140 of DNA-directed RNA polymerase II subunit RPB2
5iyb B 1119 B 1122
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1119 and 1122.
Details
Redox score ?
87
PDB code
5iyb
Structure name
human core-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
1
% buried
59
Peptide accession
P30876
Residue number A
1119
Residue number B
1122
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1122 of DNA-directed RNA polymerase II subunit RPB2
5iya B 1122 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1122 and 1140.
Details
Redox score ?
74
PDB code
5iya
Structure name
human core-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
58
Peptide accession
P30876
Residue number A
1122
Residue number B
1140
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1122 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1140 of DNA-directed RNA polymerase II subunit RPB2
5iy7 B 1122 B 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1122 and 1137.
Details
Redox score ?
69
PDB code
5iy7
Structure name
human holo-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
61
Peptide accession
P30876
Residue number A
1122
Residue number B
1137
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1122 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1137 of DNA-directed RNA polymerase II subunit RPB2
5iyd B 1137 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 1137 and 1140.
Details
Redox score ?
67
PDB code
5iyd
Structure name
human core-pic in the initial transcribing state (no iis)
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
43
Peptide accession
P30876
Residue number A
1137
Residue number B
1140
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 1137 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 1140 of DNA-directed RNA polymerase II subunit RPB2
5iy7 B 172 B 177
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 172 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
5iy7
Structure name
human holo-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
66
Peptide accession
P30876
Residue number A
172
Residue number B
177
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 172 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 177 of DNA-directed RNA polymerase II subunit RPB2
5iy7 B 357 B 572
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 357 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5iy7
Structure name
human holo-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
76
Peptide accession
P30876
Residue number A
357
Residue number B
572
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 357 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 572 of DNA-directed RNA polymerase II subunit RPB2
5iy6 B 837 B 892
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 837 and 892. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
70
Peptide accession
P30876
Residue number A
837
Residue number B
892
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 837 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 892 of DNA-directed RNA polymerase II subunit RPB2
5iy8 B 221 B 224
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 221 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5iy8
Structure name
human holo-pic in the initial transcribing state
Structure deposition date
2016-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
94
Peptide accession
P30876
Residue number A
221
Residue number B
224
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 221 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 224 of DNA-directed RNA polymerase II subunit RPB2
5iyc B 510 B 707
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 510 and 707. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5iyc
Structure name
human core-pic in the initial transcribing state
Structure deposition date
2016-03-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P30876
Residue number A
510
Residue number B
707
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 510 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 707 of DNA-directed RNA polymerase II subunit RPB2
5iy6 B 26 B 696
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB2 between cysteines 26 and 696. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
96
Peptide accession
P30876
Residue number A
26
Residue number B
696
Peptide name
DNA-directed RNA polymerase II subunit RPB2
Ligandability
Cysteine 26 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 696 of DNA-directed RNA polymerase II subunit RPB2
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