Neuronal acetylcholine receptor subunit beta-4

Intermolecular

Cysteine 269 of Neuronal acetylcholine receptor subunit alpha-3 and cysteine 260

Intramolecular

A redox-regulated disulphide may form between two units of Neuronal acetylcholine receptor subunit beta-4 at cysteines 260 and 260 (239 and 239 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6pv7

Structure name

human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine

Structure deposition date

2019-07-19

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Neuronal acetylcholine receptor subunit beta-4

Peptide B name

Neuronal acetylcholine receptor subunit beta-4

Peptide A accession

P30926

Peptide B accession

P30926

Peptide A residue number

260

Peptide B residue number

260

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 269 of Neuronal acetylcholine receptor subunit alpha-3 and cysteine 260 of Neuronal acetylcholine receptor subunit beta-4 (238 and 239 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6pv8

Structure name

human alpha3beta4 nicotinic acetylcholine receptor in complex with at- 1001

Structure deposition date

2019-07-19

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Neuronal acetylcholine receptor subunit alpha-3

Peptide B name

Neuronal acetylcholine receptor subunit beta-4

Peptide A accession

P32297

Peptide B accession

P30926

Peptide A residue number

269

Peptide B residue number

260

Ligandability

Cysteine 269 of Neuronal acetylcholine receptor subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Neuronal acetylcholine receptor subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuronal acetylcholine receptor subunit beta-4 between cysteines 153 and 167 (132 and 146 respectively in this structure).