ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-hydroxytryptamine receptor 1F

Intramolecular
Cysteine 96 and cysteine 172
Cysteine 106 and cysteine 109
Cysteine 106 and cysteine 107
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1F between cysteines 96 and 172.

Details

Redox score ?
85
PDB code
7exd
Structure name
lasmiditan-bound serotonin 1f (5-ht1f) receptor-gi protein complex
Structure deposition date
2021-05-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30939
Residue number A
96
Residue number B
172
Peptide name
5-hydroxytryptamine receptor 1F

Ligandability

Cysteine 96 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1F between cysteines 106 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7exd
Structure name
lasmiditan-bound serotonin 1f (5-ht1f) receptor-gi protein complex
Structure deposition date
2021-05-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
78
Peptide accession
P30939
Residue number A
106
Residue number B
109
Peptide name
5-hydroxytryptamine receptor 1F

Ligandability

Cysteine 106 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1F between cysteines 106 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7exd
Structure name
lasmiditan-bound serotonin 1f (5-ht1f) receptor-gi protein complex
Structure deposition date
2021-05-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
90
Peptide accession
P30939
Residue number A
106
Residue number B
107
Peptide name
5-hydroxytryptamine receptor 1F

Ligandability

Cysteine 106 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of 5-hydroxytryptamine receptor 1F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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