ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gonadotropin-releasing hormone receptor

Intramolecular
Cysteine 114 and cysteine 196
Cysteine 279 and cysteine 317
Cysteine 14 and cysteine 218
A redox-regulated disulphide may form within Gonadotropin-releasing hormone receptor between cysteines 114 and 196.

Details

Redox score ?
83
PDB code
7br3
Structure name
crystal structure of the protein 1
Structure deposition date
2020-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P30968
Residue number A
114
Residue number B
196
Peptide name
Gonadotropin-releasing hormone receptor

Ligandability

Cysteine 114 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gonadotropin-releasing hormone receptor between cysteines 279 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7br3
Structure name
crystal structure of the protein 1
Structure deposition date
2020-03-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
60
Peptide accession
P30968
Residue number A
279
Residue number B
317
Peptide name
Gonadotropin-releasing hormone receptor

Ligandability

Cysteine 279 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gonadotropin-releasing hormone receptor between cysteines 14 and 218 (1004 and 1133 respectively in this structure).

Details

Redox score ?
nan
PDB code
7br3
Structure name
crystal structure of the protein 1
Structure deposition date
2020-03-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
47
Peptide accession
P30968
Residue number A
14
Residue number B
218
Peptide name
Gonadotropin-releasing hormone receptor

Ligandability

Cysteine 14 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Gonadotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 1004 has been assigned to correct residue.
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