Neurotensin receptor type 1

Intermolecular

Cysteine 171 and cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1

Intramolecular

A redox-regulated disulphide may form between cysteine 171 of Neurotensin receptor type 1 and cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6osa

Structure name

human neurotensin receptor 1 (hntsr1) - gi1 protein complex in non- canonical conformation (nc state)

Structure deposition date

2019-05-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Neurotensin receptor type 1

Peptide B name

Guanine nucleotide-binding protein G(i) subunit alpha-1

Peptide A accession

P30989

Peptide B accession

P63096

Peptide A residue number

171

Peptide B residue number

351

Ligandability

Cysteine 171 of Neurotensin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neurotensin receptor type 1 between cysteines 141 and 224.

Details

Redox score ?

PDB code

7ul2

Structure name

cryoem structure of inactive ntsr1 bound to sr48692 and nb6

Structure deposition date

2022-04-03

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P30989

Residue number A

141

Residue number B

224

Peptide name

Neurotensin receptor type 1

Ligandability

Cysteine 141 of Neurotensin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Neurotensin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neurotensin receptor type 1 between cysteines 386 and 388. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?