ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Intermolecular
Cysteine 305 and cysteine 93 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Cysteine 305 and cysteine 113 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Cysteine 266 and cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial L
Cysteine 305 and cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial L
Intramolecular
Cysteine 189 and cysteine 191 L
Cysteine 438 and cysteine 467 L
Cysteine 287 and cysteine 574
Cysteine 189 and cysteine 190 L
Cysteine 190 and cysteine 191 L
Cysteine 266 and cysteine 305
Cysteine 287 and cysteine 443
A redox-regulated disulphide may form between cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial and cysteine 93 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (263 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3ae5
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with 2-methyl-n-(3-isopropoxy-phenyl)-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
3
% buried
100
Peptide A name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Peptide B name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Peptide A accession
Q0QF01
Peptide B accession
Q007T0
Peptide A residue number
305
Peptide B residue number
93

Ligandability

Cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial and cysteine 113 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (263 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3ae7
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(3-isopropoxy-phenyl)-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide A name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Peptide B name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Peptide A accession
Q0QF01
Peptide B accession
Q007T0
Peptide A residue number
305
Peptide B residue number
113

Ligandability

Cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 266 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial and cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6vax
Structure name
crystal structure of human sdha-adhaf2 assembly intermediate
Structure deposition date
2019-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
10
% buried
100
Peptide A name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Peptide B name
Succinate dehydrogenase assembly factor 2, mitochondrial
Peptide A accession
P31040
Peptide B accession
Q9NX18
Peptide A residue number
266
Peptide B residue number
83

Ligandability

Cysteine 266 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial and cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6vax
Structure name
crystal structure of human sdha-adhaf2 assembly intermediate
Structure deposition date
2019-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
100
Peptide A name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Peptide B name
Succinate dehydrogenase assembly factor 2, mitochondrial
Peptide A accession
P31040
Peptide B accession
Q9NX18
Peptide A residue number
305
Peptide B residue number
83

Ligandability

Cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Succinate dehydrogenase assembly factor 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 189 and 191.

Details

Redox score ?
72
PDB code
6vax
Structure name
crystal structure of human sdha-adhaf2 assembly intermediate
Structure deposition date
2019-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
7
% buried
85
Peptide accession
P31040
Residue number A
189
Residue number B
191
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 189 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 438 and 467.

Details

Redox score ?
63
PDB code
6vax
Structure name
crystal structure of human sdha-adhaf2 assembly intermediate
Structure deposition date
2019-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
105
Minimum pKa ?
9
% buried
100
Peptide accession
P31040
Residue number A
438
Residue number B
467
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 438 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 467 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 287 and 574. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6vax
Structure name
crystal structure of human sdha-adhaf2 assembly intermediate
Structure deposition date
2019-12-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
107
Minimum pKa ?
12
% buried
100
Peptide accession
P31040
Residue number A
287
Residue number B
574
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 287 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 189 and 190 (147 and 148 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3ae7
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(3-isopropoxy-phenyl)-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
99
Minimum pKa ?
13
% buried
100
Peptide accession
Q0QF01
Residue number A
189
Residue number B
190
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 189 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 190 and 191 (148 and 149 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3ae8
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with n-(3-isopropoxy-phenyl)-2-trifluoromethylbenzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
100
Peptide accession
Q0QF01
Residue number A
190
Residue number B
191
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 190 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 266 and 305 (224 and 263 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3ae3
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with 2-nitro-n-phenyl-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
100
Peptide accession
Q0QF01
Residue number A
266
Residue number B
305
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 266 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial between cysteines 287 and 443 (245 and 401 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3ae9
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with n-(3-pentafluorophenyloxy-phenyl)-2-trifluoromethyl-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
Q0QF01
Residue number A
287
Residue number B
443
Peptide name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Ligandability

Cysteine 287 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 443 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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