ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rab GDP dissociation inhibitor alpha

Intramolecular
Cysteine 282 and cysteine 400
Cysteine 400 and cysteine 402
Cysteine 317 and cysteine 335
A redox-regulated disulphide may form within Rab GDP dissociation inhibitor alpha between cysteines 282 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
1lv0
Structure name
crystal structure of the rab effector guanine nucleotide dissociation inhibitor (gdi) in complex with a geranylgeranyl (gg) peptide
Structure deposition date
2002-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
94
Peptide accession
P21856
Residue number A
282
Residue number B
400
Peptide name
Rab GDP dissociation inhibitor alpha

Ligandability

Cysteine 282 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab GDP dissociation inhibitor alpha between cysteines 400 and 402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1lv0
Structure name
crystal structure of the rab effector guanine nucleotide dissociation inhibitor (gdi) in complex with a geranylgeranyl (gg) peptide
Structure deposition date
2002-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
76
Peptide accession
P21856
Residue number A
400
Residue number B
402
Peptide name
Rab GDP dissociation inhibitor alpha

Ligandability

Cysteine 400 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 402 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab GDP dissociation inhibitor alpha between cysteines 317 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
1d5t
Structure name
guanine nucleotide dissociation inhibitor, alpha-isoform
Structure deposition date
1999-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
12
% buried
100
Peptide accession
P21856
Residue number A
317
Residue number B
335
Peptide name
Rab GDP dissociation inhibitor alpha

Ligandability

Cysteine 317 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Rab GDP dissociation inhibitor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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