ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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S-adenosylmethionine synthase isoform type-2

Intramolecular
Cysteine 149 and cysteine 311
Cysteine 34 and cysteine 56 L
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-2 between cysteines 149 and 311. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6fcd
Structure name
human methionine adenosyltransferase ii mutant (r264a)
Structure deposition date
2017-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
83
Peptide accession
P31153
Residue number A
149
Residue number B
311
Peptide name
S-adenosylmethionine synthase isoform type-2

Ligandability

Cysteine 149 of S-adenosylmethionine synthase isoform type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of S-adenosylmethionine synthase isoform type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-2 between cysteines 34 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7kcc
Structure name
crystal structure of human methionine adenosyltransferase 2a (mat2a) in complex with sam and allosteric inhibitor ag-270
Structure deposition date
2020-10-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
97
Peptide accession
P31153
Residue number A
34
Residue number B
56
Peptide name
S-adenosylmethionine synthase isoform type-2

Ligandability

Cysteine 34 of S-adenosylmethionine synthase isoform type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of S-adenosylmethionine synthase isoform type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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