a tool for identifying drug-targetable redox-active disulphides

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Intramolecular

Cysteine 5 and cysteine 133

A redox-regulated disulphide may form within 3-oxo-5-alpha-steroid 4-dehydrogenase 2 between cysteines 5 and 133.

Details

Redox score ?

88

PDB code

Structure name

crystal structure of steroid 5-alpha-reductase 2 in complex with finasteride

Structure deposition date

2020-04-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

5

Residue number B

133

Peptide name

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Ligandability

Cysteine 5 of 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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