Carbamoyl-phosphate synthase [ammonia], mitochondrial
Intramolecular
Cysteine 1049 and cysteine 1052
Cysteine 981 and cysteine 1015
Cysteine 816 and cysteine 1015
Cysteine 644 and cysteine 697
Cysteine 644 and cysteine 761
Cysteine 981 and cysteine 995
6w2j A 1049 A 1052
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 1049 and 1052. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6w2j
Structure name
cps1 bound to allosteric inhibitor h3b-374
Structure deposition date
2020-03-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
91
Peptide accession
P31327
Residue number A
1049
Residue number B
1052
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 1049 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 1052 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
6uel B 981 B 1015
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 981 and 1015. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6uel
Structure name
cps1 bound to allosteric inhibitor h3b-193
Structure deposition date
2019-09-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
103
Minimum pKa ?
12
% buried
100
Peptide accession
P31327
Residue number A
981
Residue number B
1015
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 981 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 1015 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
6uel A 816 A 1015
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 816 and 1015. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6uel
Structure name
cps1 bound to allosteric inhibitor h3b-193
Structure deposition date
2019-09-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
P31327
Residue number A
816
Residue number B
1015
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 816 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 1015 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
6uel B 644 B 697
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 644 and 697. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6uel
Structure name
cps1 bound to allosteric inhibitor h3b-193
Structure deposition date
2019-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
P31327
Residue number A
644
Residue number B
697
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 644 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 697 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
6w2j B 644 B 761
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 644 and 761. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6w2j
Structure name
cps1 bound to allosteric inhibitor h3b-374
Structure deposition date
2020-03-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
P31327
Residue number A
644
Residue number B
761
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 644 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 761 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
6uel A 981 A 995
A redox-regulated disulphide may form within Carbamoyl-phosphate synthase [ammonia], mitochondrial between cysteines 981 and 995. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
6uel
Structure name
cps1 bound to allosteric inhibitor h3b-193
Structure deposition date
2019-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
P31327
Residue number A
981
Residue number B
995
Peptide name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Ligandability
Cysteine 981 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
Cysteine 995 of Carbamoyl-phosphate synthase [ammonia], mitochondrial
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