a tool for identifying drug-targetable redox-active disulphides

Ribonucleoside-diphosphate reductase subunit M2

Intramolecular

Cysteine 270 and cysteine 274

A redox-regulated disulphide may form within Ribonucleoside-diphosphate reductase subunit M2 between cysteines 270 and 274.

Details

Redox score ?

63

PDB code

Structure name

crystal structure of human ribonucleotide reductase subunit r2

Structure deposition date

2007-03-16

Thiol separation (Å)

5

Half-sphere exposure sum ?

74

Minimum pK_a ?

9

% buried

92

Peptide accession

Residue number A

270

Residue number B

274

Peptide name

Ribonucleoside-diphosphate reductase subunit M2

Ligandability

Cysteine 270 of Ribonucleoside-diphosphate reductase subunit M2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Ribonucleoside-diphosphate reductase subunit M2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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