a tool for identifying drug-targetable redox-active disulphides

Somatostatin receptor type 4

Intramolecular

Cysteine 119 and cysteine 198

A redox-regulated disulphide may form within Somatostatin receptor type 4 between cysteines 119 and 198.

Details

Redox score ?

83

PDB code

Structure name

cryoem structure of somatostatin receptor 4 (sstr4) in complex with gi1 and its endogeneous ligand sst-14

Structure deposition date

2022-04-26

Thiol separation (Å)

2

Half-sphere exposure sum ?

72

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

119

Residue number B

198

Peptide name

Somatostatin receptor type 4

Ligandability

Cysteine 119 of Somatostatin receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Somatostatin receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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