ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Sodium/glucose cotransporter 2

Intramolecular
Cysteine 517 and cysteine 522
Cysteine 345 and cysteine 351
Cysteine 255 and cysteine 511
Cysteine 355 and cysteine 361
Cysteine 351 and cysteine 361
Cysteine 345 and cysteine 361
Cysteine 301 and cysteine 314
Cysteine 345 and cysteine 355
Cysteine 351 and cysteine 355
Cysteine 314 and cysteine 317
More...
Cysteine 351 and cysteine 511
Cysteine 292 and cysteine 314
Cysteine 301 and cysteine 317
Cysteine 292 and cysteine 301
A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 517 and 522.

Details

Redox score ?
88
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
517
Residue number B
522
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 517 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 345 and 351.

Details

Redox score ?
83
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
345
Residue number B
351
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 345 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 255 and 511.

Details

Redox score ?
82
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
255
Residue number B
511
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 255 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 511 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 355 and 361.

Details

Redox score ?
80
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
355
Residue number B
361
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 355 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 351 and 361.

Details

Redox score ?
66
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
351
Residue number B
361
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 351 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 345 and 361.

Details

Redox score ?
66
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
345
Residue number B
361
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 345 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 301 and 314.

Details

Redox score ?
61
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
105
Minimum pKa ?
9
% buried
100
Peptide accession
P31639
Residue number A
301
Residue number B
314
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 301 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 345 and 355.

Details

Redox score ?
60
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
345
Residue number B
355
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 345 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 351 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
351
Residue number B
355
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 351 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 314 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
96
Minimum pKa ?
9
% buried
100
Peptide accession
P31639
Residue number A
314
Residue number B
317
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 314 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 351 and 511. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31639
Residue number A
351
Residue number B
511
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 351 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 511 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 292 and 314. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
9
% buried
100
Peptide accession
P31639
Residue number A
292
Residue number B
314
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 292 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 301 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
101
Minimum pKa ?
13
% buried
100
Peptide accession
P31639
Residue number A
301
Residue number B
317
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 301 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/glucose cotransporter 2 between cysteines 292 and 301. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7vsi
Structure name
structure of human sglt2-map17 complex bound with empagliflozin
Structure deposition date
2021-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
13
% buried
100
Peptide accession
P31639
Residue number A
292
Residue number B
301
Peptide name
Sodium/glucose cotransporter 2

Ligandability

Cysteine 292 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of Sodium/glucose cotransporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: