ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid receptor subunit alpha-5

Intramolecular
Cysteine 268 and cysteine 327
Cysteine 173 and cysteine 187
A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-5 between cysteines 268 and 327 (237 and 296 respectively in this structure).

Details

Redox score ?
62
PDB code
5ojm
Structure name
structure of a chimaeric beta3-alpha5 gabaa receptor in complex with nanobody nb25
Structure deposition date
2017-07-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
94
Peptide accession
P31644
Residue number A
268
Residue number B
327
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-5

Ligandability

Cysteine 268 of Gamma-aminobutyric acid receptor subunit alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 327 of Gamma-aminobutyric acid receptor subunit alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-5 between cysteines 173 and 187 (136 and 150 respectively in this structure).

Details

Redox score ?
nan
PDB code
5o8f
Structure name
structure of a chimaeric beta3-alpha5 gabaa receptor in complex with nanobody nb25 and pregnanolone
Structure deposition date
2017-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31644
Residue number A
173
Residue number B
187
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-5

Ligandability

Cysteine 173 of Gamma-aminobutyric acid receptor subunit alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Gamma-aminobutyric acid receptor subunit alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 150 has been assigned to correct residue.
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