ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RAC-alpha serine/threonine-protein kinase

Intramolecular
Cysteine 60 and cysteine 77
Cysteine 296 and cysteine 310
A redox-regulated disulphide may form within RAC-alpha serine/threonine-protein kinase between cysteines 60 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
1h10
Structure name
high resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to ins(1,3,4,5)-tetrakisphophate
Structure deposition date
2002-07-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
58
Peptide accession
P31749
Residue number A
60
Residue number B
77
Peptide name
RAC-alpha serine/threonine-protein kinase

Ligandability

Cysteine 60 of RAC-alpha serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of RAC-alpha serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAC-alpha serine/threonine-protein kinase between cysteines 296 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
3ocb
Structure name
akt1 kinase domain with pyrrolopyrimidine inhibitor
Structure deposition date
2010-08-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
90
Peptide accession
B2RAM5
Residue number A
296
Residue number B
310
Peptide name
RAC-alpha serine/threonine-protein kinase

Ligandability

Cysteine 296 of RAC-alpha serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of RAC-alpha serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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