ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RAC-beta serine/threonine-protein kinase

Intramolecular
Cysteine 60 and cysteine 77
Cysteine 297 and cysteine 311
A redox-regulated disulphide may form within RAC-beta serine/threonine-protein kinase between cysteines 60 and 77.

Details

Redox score ?
85
PDB code
1p6s
Structure name
solution structure of the pleckstrin homology domain of human protein kinase b beta (pkb/akt)
Structure deposition date
2003-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31751
Residue number A
60
Residue number B
77
Peptide name
RAC-beta serine/threonine-protein kinase

Ligandability

Cysteine 60 of RAC-beta serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of RAC-beta serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RAC-beta serine/threonine-protein kinase between cysteines 297 and 311. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3e87
Structure name
crystal structures of the kinase domain of akt2 in complex with atp- competitive inhibitors
Structure deposition date
2008-08-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
98
Peptide accession
P31751
Residue number A
297
Residue number B
311
Peptide name
RAC-beta serine/threonine-protein kinase

Ligandability

Cysteine 297 of RAC-beta serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of RAC-beta serine/threonine-protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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