Cytokine receptor common subunit gamma
Intermolecular
Cysteine 27 of Interleukin-4 and cysteine 231
Cysteine 27 of Interleukin-4 and cysteine 182
Cysteine 151 of Interleukin-4 and cysteine 231
Cysteine 27 of Interleukin-4 and cysteine 231
Cysteine 151 of Interleukin-4 and cysteine 182
Cysteine 151 of Interleukin-4 and cysteine 231
Cysteine 151 of Interleukin-4 and cysteine 182
Cysteine 27 of Interleukin-4 and cysteine 182
Intramolecular
Cysteine 102 and cysteine 115
Cysteine 62 and cysteine 72
More...Cysteine 182 and cysteine 231
Cysteine 72 and cysteine 115
Cysteine 72 and cysteine 102
Cysteine 62 and cysteine 115
Cysteine 62 and cysteine 102
3bpl A 3 C 209
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (3 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
231
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3bpl A 3 C 160
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (3 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
182
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3qb7 A 127 C 209
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (127 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
231
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3qb7 B 3 D 209
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (3 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
231
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3qb7 A 127 C 160
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (127 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
182
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3bpl A 127 C 209
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (127 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
231
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3bpl A 127 C 160
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (127 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
182
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3qb7 B 3 D 160
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (3 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
182
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3qaz d 80 d 93
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 102 and 115 (80 and 93 respectively in this structure).
Details
Redox score ?
86
PDB code
3qaz
Structure name
il-2 mutant d10 ternary complex
Structure deposition date
2011-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
102
Residue number B
115
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 102 of Cytokine receptor common subunit gamma
Cysteine 115 of Cytokine receptor common subunit gamma
7s2r A 62 A 72
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 62 and 72.
Details
Redox score ?
84
PDB code
7s2r
Structure name
nanobody bound to il-2rg
Structure deposition date
2021-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
62
Residue number B
72
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 62 of Cytokine receptor common subunit gamma
Cysteine 72 of Cytokine receptor common subunit gamma
3qaz O 160 O 209
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 182 and 231 (160 and 209 respectively in this structure).
Details
Redox score ?
79
PDB code
3qaz
Structure name
il-2 mutant d10 ternary complex
Structure deposition date
2011-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
182
Residue number B
231
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 182 of Cytokine receptor common subunit gamma
Cysteine 231 of Cytokine receptor common subunit gamma
6dg5 C 72 C 115
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 72 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6dg5
Structure name
structure of a de novo designed interleukin-2/interleukin-15 mimetic complex with il-2rb and il-2rg
Structure deposition date
2018-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P34902
Residue number A
72
Residue number B
115
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 72 of Cytokine receptor common subunit gamma
Cysteine 115 of Cytokine receptor common subunit gamma
5m5e C 50 C 80
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 72 and 102 (50 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
5m5e
Structure name
crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Structure deposition date
2016-10-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
72
Residue number B
102
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 72 of Cytokine receptor common subunit gamma
Cysteine 102 of Cytokine receptor common subunit gamma
3qaz g 40 g 93
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 62 and 115 (40 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3qaz
Structure name
il-2 mutant d10 ternary complex
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
62
Residue number B
115
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 62 of Cytokine receptor common subunit gamma
Cysteine 115 of Cytokine receptor common subunit gamma
3qb7 D 40 D 80
A redox-regulated disulphide may form within Cytokine receptor common subunit gamma between cysteines 62 and 102 (40 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31785
Residue number A
62
Residue number B
102
Peptide name
Cytokine receptor common subunit gamma
Ligandability
Cysteine 62 of Cytokine receptor common subunit gamma
Cysteine 102 of Cytokine receptor common subunit gamma
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