ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytochrome b-c1 complex subunit 1, mitochondrial

Intramolecular
Cysteine 380 and cysteine 445
Cysteine 338 and cysteine 360
Cysteine 316 and cysteine 338
Cysteine 69 and cysteine 410
A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 1, mitochondrial between cysteines 380 and 445 (346 and 411 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7o3c
Structure name
murine supercomplex ciii2civ in the mature unlocked conformation
Structure deposition date
2021-04-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
100
Peptide accession
Q9CZ13
Residue number A
380
Residue number B
445
Peptide name
Cytochrome b-c1 complex subunit 1, mitochondrial

Ligandability

Cysteine 380 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 445 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 1, mitochondrial between cysteines 338 and 360 (304 and 326 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7o3c
Structure name
murine supercomplex ciii2civ in the mature unlocked conformation
Structure deposition date
2021-04-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
91
Peptide accession
Q9CZ13
Residue number A
338
Residue number B
360
Peptide name
Cytochrome b-c1 complex subunit 1, mitochondrial

Ligandability

Cysteine 338 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 1, mitochondrial between cysteines 316 and 338 (282 and 304 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7o3c
Structure name
murine supercomplex ciii2civ in the mature unlocked conformation
Structure deposition date
2021-04-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
84
Peptide accession
Q9CZ13
Residue number A
316
Residue number B
338
Peptide name
Cytochrome b-c1 complex subunit 1, mitochondrial

Ligandability

Cysteine 316 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit 1, mitochondrial between cysteines 69 and 410 (35 and 376 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1bgy
Structure name
cytochrome bc1 complex from bovine
Structure deposition date
1998-06-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
96
Peptide accession
P31800
Residue number A
69
Residue number B
410
Peptide name
Cytochrome b-c1 complex subunit 1, mitochondrial

Ligandability

Cysteine 69 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Cytochrome b-c1 complex subunit 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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