a tool for identifying drug-targetable redox-active disulphides

3-hydroxyisobutyrate dehydrogenase, mitochondrial

Intermolecular

Cysteine 251 and cysteine 251

A redox-regulated disulphide may form between two units of 3-hydroxyisobutyrate dehydrogenase, mitochondrial at cysteines 251 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

54

PDB code

Structure name

crystal structure of human hydroxyisobutyrate dehydrogenase

Structure deposition date

2006-03-21

Thiol separation (Å)

6

Half-sphere exposure sum ?

96

Minimum pK_a ?

10

% buried

100

Peptide A name

3-hydroxyisobutyrate dehydrogenase, mitochondrial

Peptide B name

3-hydroxyisobutyrate dehydrogenase, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

251

Peptide B residue number

251

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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