DNA dC->dU-editing enzyme APOBEC-3A

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of DNA dC->dU-editing enzyme APOBEC-3A at cysteines 64 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5sww

Structure name

crystal structure of human apobec3a complexed with ssdna

Structure deposition date

2016-08-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

DNA dC->dU-editing enzyme APOBEC-3A

Peptide B name

DNA dC->dU-editing enzyme APOBEC-3A

Peptide A accession

P31941

Peptide B accession

P31941

Peptide A residue number

Peptide B residue number

171

Ligandability

Cysteine 64 of DNA dC->dU-editing enzyme APOBEC-3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of DNA dC->dU-editing enzyme APOBEC-3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA dC->dU-editing enzyme APOBEC-3A between cysteines 101 and 106.

Details

Redox score ?

PDB code

5sww

Structure name

crystal structure of human apobec3a complexed with ssdna

Structure deposition date

2016-08-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P31941

Residue number A

101

Residue number B

106

Peptide name

DNA dC->dU-editing enzyme APOBEC-3A

Ligandability

Cysteine 101 of DNA dC->dU-editing enzyme APOBEC-3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of DNA dC->dU-editing enzyme APOBEC-3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA dC->dU-editing enzyme APOBEC-3A between cysteines 34 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?